CAMP4 was born from seminal discoveries made by founders Dr. Richard Young and Dr. Leonard Zon, characterizing the ways in which dynamic cell signaling networks control the expression of genes. The following are key publications detailing their landmark work:

Mullen, A.C., Orlando,D.A., Newman, J.J., Lovén, J., Kumar, R.M., Bilodeau, S., Guenther, M.G., DeKoter, R., and Young, R.A.

Master transcription factors determine the gene targets of the TGF-β pathway.

Cell 147: 565-576 (2011)
Trompouki, E., Bowman, T.V., Lawton, L.N., Fan, Z.P., Wu, D.-C., DiBiase, A., Martin, C.S., Cech, J.N., Sessa, A.K., Leblanc, J.L., Li, P., Durand, E., Mosimann, C., Heffner, G.C., Daley, G.Q., Paulson, R.F., Young, R.A. and Zon, L.N. BMP and Wnt

Pathway regulation of lineage-specific gene programs underlie hematopoietic regeneration.

Cell 147: 577-589 (2011)
Hnisz, D., Weintraub, A.S, Day, D.S., Valton, A.-L., Bak, R.O., Li, C.H., Goldmann, J., Lajoie, B.R., Fan, Z.P, Sigova, A.A., Reddy, J., Borges-Rivera, D., Lee, T.I., Jaenisch, R., Porteus, M.H., Dekker, J., and Young, R.A.

Activation of proto-oncogenes by disruption of chromosome neighborhoods.

Science 351: 1454-1458 (2016)
Dowen, J.M., Fan, Z.P., Hnisz, D., Ren, G., Abraham, B.J., Zhang, L., Weintraub, A.S., Schujiers, J., Lee, T.I., Zhao, K. and Young, R.A.

Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes.

Cell 159: 374–387 (2014)
Hnisz, D., Day, D.S. and Young, R.A.

Insulated neighborhoods: structural and functional units of mammalian gene control.

Cell 167:1188-1200 (2016)
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